Uzm. Dr. Hatice KARAKÖSE DOĞAN

• Tiroid hastalıkları
• Paratiroid Hastalıkları
• Osteoporoz 
• Diyabet 
• Obezite 
• Hiperlipidemi
• Hirsutizm
• Polikistik Over Sendromu
• Hipofiz Hastalıkları
• Adrenal Bez Hastalıkları

• 1994-1999 Çukurova Üniversitesi Tıp Fakültesi Dr.Ar.Gör.
• 1999-2000 Başkent Üniversitesi Tıp Fakültesi Uzm. Dr.  
• 2000-2003 Başkent Üniversitesi Tıp Fakültesi Yan Dal İhtis.
• 2003-2004 Başkent Üniversitesi Tıp Fakültesi Öğrt.Gör. Dr.
• 2004-2005 Özel Keçiören Hastanesi Uzm. Dr.
• 2005- 2007 TOBB ETÜ  Hastanesi Uzm. Dr.
• 2007-2011Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Uzm. Dr.
• 2011-2018 Kayseri Eğitim ve Araştırma Hastanesi Uzm. Dr.
• 2019-2021 Özel Acıbadem Kayseri Hastanesi Uzm. Dr.
• 2021-2022 Kayseri Şehir Hastanesi Uzm. Dr.
• 2022-2023 Sancaktepe Şehit Prof.Dr. İlhan Varank Eğitim ve Araştırma  Hastanesi Uzm. Dr.

A. Uluslararası hakemli dergilerde yayımlanan makaleler :

A1.      Relationship of Helicobacter pylori infection to several malignant and non-malignant gastrointestinal diseases. J Exp. Clin. Cancer Res. 16.3.1997 P289-293

A2.   Gokcel A, Karakose H, Ertorer EM, Tanaci N, Tutuncu NB, Guvener N. Effects of Sibutramine in Obese Females with Type 2 Diabetes Mellitus and Poor Blood Glucose Control. Diabetes Care 2001; 24: 1957-1960.

A3.      Gokcel A, Gumurdulu Y, Karakose H, Ertorer EM, Tanaci N, Tutuncu NB, Guvener N. Evaluation of the Safety and Efficacy of Sibutramine, Orlistat, and Metformin in the Treatment of Obesity. Diabetes Obesity & Metabolism 2002; 4: 49-55.

A4.      Gokcel A, Gumurdulu Y, Karakose H, Karademir MB, Anarat R. Effects of Sibutramine in Nondieting Obese Women. Journal of Endocrinological Investigation 2002; 25: 101-105.

A5.      Gokcel A, Baltali M, Tarim E, Bagis T, Gumurdulu Y, Karakose H, Yalcin F, Guvener N. Detection of Insulin Resistance in Turkish Adults: A Hospital Based Study. Diabetes Obesity & Metabolism 2003; 5: 126-130.

A6.      Gokcel A, Ozsahin AK, Sezgin N, Karakose H, Ertorer ME, Akbaba M, Baklaci N, Sengul A, Guvener N. High Prevalence of Diabetes in Adana; a Southern Province of Turkey. Diabetes Care 2003; 26: 3031-3034.

B. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler :

B1.      Gokcel A, Gumurdulu Y, Karakose H, Karademir BM, Anarat R. Effects of Sibutramine on Leptin Levels in Non-Dieting Obese Women. 10^th European Congress Antwerp-Belgium, 24-27 May, 2000 (Poster Sunum)

B2.      Gokcel A, Gumurdulu Y, Karakose H, Ertorer EM, Tanaci N, Tutuncu NB, Guvener N. Evaluation of the Safety and Efficacy of Sibutramine, Orlistat, and Metformin in the Treatment of Obesity. 11^th European Congress on Obesity Vienna; 30 May – 2 June, 2001 (Poster Sunum) (Aynı zamanda 24^th Congress of Endocrinology and Metabolic diseases of Turkey Joint Meeting with the American Association of Clinical Endocrinologists; Sözlü Sunum)

B3.      Gokcel A, Karakose H, Ertorer EM, Tanaci N, Tutuncu NB, Guvener N. Effects of Sibutramine in Obese Females with Type 2 Diabetes Mellitus and Poor Blood Glucose Control. 11^th European Congress on Obesity Vienna; 30 May – 2 June, 2001 (Poster Sunum) (Aynı zamanda 24^th Congress of Endocrinology and Metabolic diseases of Turkey Joint Meeting with the American Association of Clinical Endocrinologists; Poster Sunum)

B4.      Gokcel A, Gumurdulu Y, Karakose H, Ertorer E, Tanacı N, Tutuncu NB, Guvener N. Evaluation of the safety and efficiacy of sibutramine, orlistat and metformin in the treatment of obesity.   11^th European Congress on Obesity ( EASO)  30 May – 2 June, 2001, Vienna, Austria. ( Özet kitabında yer aldı ).   

B5.      Karakose H, Tutuncu NB, Tanacı N, Guvener N, Haberal M.  Hypercalcemia with elevated parathyroid hormone levels in patients receiving mycophenolate mofetil.  XXXVIII.Congress of the European Renal Association. European Dialysis and Transplant Association. June 24-27, 2001  Vienna, Austria (Özet kitabında yer aldı).

B6.      Tanacı N, Karakose H, Guvener N, Tutuncu NB, Colak T, Haberal M. Influence of 1,25-Dihydroxyvitamin D3 as an immunomodulator in renal transplant recipients: A retrospective cohort study. XXXVIII.Congress of the European Renal Association. European Dialysis and Transplant Association. June 24-27, 2001  Vienna, Austria ( Sözlü sunum ).

 B7.      Tanacı N, Karakose H, Guvener N, Bascıl Tutuncu N, Colak T, Haberal M.  Risk factor analysis in ranal tansplant recipients. A matched-pair control study.  XXXVIII.Congress of the European Renal Association. European Dialysis and Transplant Association. June 24-27, 2001  Vienna, Austria (Özet kitabında yer aldı).

B8.      Gokcel A, Aydin M, Müderrisoglu H, Ertorer ME, Yapar AF, Karakose H. Silent Coronary Artery Disease in Type 2 Diabetes Mellitus. 11^th Balkan Congress of Endocrinology Istanbul; 2-3 October, 2001 (Poster Sunum)

B9.      Gokcel A, Baltali M, Tarim E, Bagis T, Gumurdulu Y, Karakose H, Guvener N. Detection of Insulin Resistance in Turkish Adults: a Hospital Based Study. 6^th European Congress of Endocrinology Lyon, 26-30 April 2003 (Poster Sunum) (Aynı zamanda 25. Ulusal Endokrinoloji ve Metabolik Hastalıklar Kongresi Erzurum, 18-21 Eylül 2002; Poster Sunum)

B10.    Gokcel A, Ozsahin AK, Karakose H, Ertorer ME, Baklaci N, Sengul A, Guvener N, Akbaba M. Prevalence of Diabetes, Obesity, Dyslipidemia and Hypertension in Adana-Turkey: Preliminary Results of Baskent University Diabetes Assessment (BUDA) Study. 18^th International Diabetes Federation Congress Paris; 24-29 Agustos, 2003 (Poster Sunum)

C. Ulusal hakemli dergilerde yayımlanan makaleler :

C1.     Aslan H, Karaköse H.  Romatoid Artriti Olan Kadın Hastalarda Beden Algısı, Benlik Saygısı, Aleksitimi, Depresyon ve Kaygı. Düşünen Adam.  1996; 9(4): 23-27.  

C2.    Karakurum B, Karataş M, Ergin P, Karaköse H, Bereketoğlu MA, Güz G.  Üremik Olgularda Sefepim Kullanımı Ile Ortaya Çıkan Aksiyon Myoklonusu: İki Olgu Sunumu. Parkinson Hastalığı  Ve Hareket Bozuklukları Dergisi. 2001; 2: 103-107.    

C3.      Yalçın F, Karaköse H, Gökçel A, Yiğit F, Yalçın H, Yapar F, Korkmaz ME, Müderrisoğlu H. Diyabetik ve Diyabetik Olmayan Koroner Arter Hastalarında Cytomegalovirus Sıklığı. Klinik Bilimler & Doktor 2002; 8: 563-567.

C4.      Kayaselçuk F, Gökçel A, Bal N, Karaköse H, Bolat FA, Yıldırım S, Ertörer E, Reyhan M, Özşahin K. Tiroid Nodüllerini Değerlendirmede İnce İğne Aspirasyon Biyopsisinin Yeri. 1134 Olguluk Seri Sunumu. Endokrinolojide Yönelişler 2003; 12:160-162.

D. Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında basılan bildiriler:

D1.      Gökçel A, Gümürdülü Y, Karaköse H, Karademir BM. Leptin is Associated with Increased Cardiovascular Risk Factors. Presented in 23^rd Congress of Endocrinology and Metabolic Diseases of Turkey Joint Meeting with the European Federation of Endocrine Societies Ankara-Turkey, 7-9 September, 2000 (Poster Sunum)

D2.      Aydın M, Gökçel A, Yapar AF, Yologlu NA, Yalçın H, Ertörer ME, Karaköse H. Tip 2 Diabetes Mellitus Hastalarında Sessiz İskemi İnsidansının Tc-99m Tetrofosmin Miyokard Perfüzyon Sintigrafisi ile Araştırılması. XIV. Ulusal Nükleer Tıp Kongresi Gaziantep, 10-13 Mayıs 2001 (Poster Sunum)

D3.      Karaköse H, Tanacı N, Gökçel A, Tütüncü NB, Güvener N. Hypercalcemia with Elevated Parathyroid Hormone Levels in a Patient Receiving Mycophenolate Mofetil. 24^th Congress of Endocrinology and Metabolic diseases of Turkey Joint Meeting with the American Association of Clinical Endocrinologists, İstanbul 4-6 Ekim 2001 (Poster Sunum)

D4.     Gokcel A, Gumurdulu Y, Karakose H, Ertorer EM, Tanacı N, Tutuncu NB, Guvener N. Efficiacy of Sibutramine, Orlistat and Metformin in the Treatment of Obesity. 24^th Congress of Endocrinology and Metabolic diseases of Turkey Joint Meeting with the American Association of Clinical Endocrinologists, İstanbul 4-6 Ekim 2001 (Sözlü  Sunum)

D5.     Gokcel A, Karakose H, Ertorer EM, Tanacı N, Tutuncu NB, Guvener N.  Effects of Sibutramine in Obse Females with Type 2 Diabetes Mellitus and Poor Blood Glucose Control. 24^th Congress of Endocrinology and Metabolic diseases of Turkey Joint Meeting with the American Association of Clinical Endocrinologists, İstanbul 4-6 Ekim 2001 ( Poster  Sunum)

D6.    Gökçel A, Güvener N, Ertörer E, Tanacı N, Karaköse H, Tütüncü NB. Diabetik Nöropati Gelişiminde C-Peptidin Koruyucu Rolü. 38. Ulusal Diabet Kongresi Antalya, 13-17 Mayıs 2002 (Sözlü Bildiri)

D7.      Karaköse H, Gökçel A, Ertörer E, Tanacı N, Tütüncü NB, Güvener N. Gebeliğin İndüklediği Cushing Sendromu. 25. Ulusal Endokrinoloji ve Metabolik Hastalıklar Kongresi Erzurum, 18-21 Eylül 2002 (Poster Sunum)

D8.      Ertörer ME, Bağış T, Karaköse H, Gökçel A, Tütüncü NB. 46XX, Gonadal Disgenezis ve Müllerien Hipoplazi Birlikteliği Olan Bir Diabetes Mellitus Olgusu. 25. Ulusal Endokrinoloji ve Metabolik Hastalıklar Kongresi Erzurum, 18-21 Eylül 2002 (Poster Sunum)

D9.      Gokcel A, Baltalı M, Tarım E, Bagıs T, Gumurdulu Y,Karakose H, Yalçın F, Guvener N. Hastane Populasyonumuzda İnsulin Rezistansı.   25. Ulusal Endokrinoloji ve Metabolik Hastalıklar Kongresi Erzurum, 18-21 Eylül 2002 (Poster Sunum)

D10.     Tarım E, Gokcel A, Karakose H, Bagıs T, Kıllıcadağ E.  Tibolonun Tiroid Fonksiyonuna Etkisi.  . 25. Ulusal Endokrinoloji ve Metabolik Hastalıklar Kongresi Erzurum, 18-21 Eylül 2002 (Poster Sunum)

D11.    Gökçel A, Özşahin AK, Sezgin N, Karaköse H, Ertörer ME, Akbaba M, Baklacı N, Şengül A, Güvener N. Güney Anadolu Kenti Adana’da Yüksek Diyabet Prevalansı. 39. Ulusal Diyabet Kongresi İstanbul, 12-16 Mayıs 2003 (Poster Sunum)

E. Atıfta Bulunulan Yayınlar :

E1. Gokcel A, Karakose H, Ertorer EM, Tanaci N, Tutuncu NB, Guvener N. Effects of Sibutramine in Obese Females with Type 2 Diabetes Mellitus and Poor Blood Glucose Control. Diabetes Care 2001; 24: 1957-1960.

1.     Dube DS, Peiris AN. Concise Update to Managing Adult Diabetes. Southern Med J 2002; 95: 4-9.

2.     Snider LJ, Malone M. Orlistat Use in Type 2 Diabetes. Ann Pharmacother 2002; 36: 1210-1218.

3.     Pischon T, Sharma AM. Recent Developments in the Treatment of Obesity-Related Hypertension. Curr Opin Nephrol Hy 2002; 11: 497-502.

4.     Mooradian AD. Cardiovascular Disease in Type 2 Diabetes Mellitus: Current Management Guidelines. Arch Intern Med 2003; 163: 33-40.

5.     Sum CF. Pharmacotherapy and Surgery in the Treatment of Obesity: Evaluating Risks and Benefits. Asia Pac J Clin Nutr 2002; 11 (Suppl 8): S722-S725.

6.     Scheen AJ, Ernest PH. New Antiobesity Agents in Type 2 Diabetes: Overview of Clinical Trials with Sibutramine and Orlistat. Diabetes Metab 2002; 28: 437-445.

7.     Halpern A, Mancini MC. Treatment of Obesity: an Update on Anti-Obesity Medications. Obesity Reviews 2003; 4: 25-42.

8.     Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagne J. Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic Performance: a Meta-Analysis. JAMA 2003; 289: 1537-1545.

9.     Scheen AJ. Current management strategies for coexisting diabetes mellitus and obesity. Drugs 2003; 63: 1165-1184.

10.  Ryan DH. Use of sibutramine to treat obesity. Primary Care 2003; 30: 405-

11.  Albu J, Raha-Khan N. the management of the obese diabetic patient. Primary Care 2003; 30: 465-

12.  Redmon JB, Raatz SK, Reck KP, Swanson JE, Kwong CA, Fan Q, Thomas W, Bantle JP. One-Year Outcome of a Combination of Weight Loss Therapies for Subjects
with Type 2 Diabetes: A randomized trial. Diabetes Care 2003 26: 2505-2511.

13.  Hauner H, Meier M, Tockel KH, Frey UH, Siffert W. Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta 3 subunit gene (GNB3) C825T polymorphism. Pharmacogenetics 2003; 3:453-459.

14.   Kim SH, Lee YM, Jee SH, Nam CM. Effect of sibutramine on weight loss and blood pressure: a meta-analysis of controlled trials. Obesity Research 2003; 11:1116-1123

15.   Steinmetz A. Treatment of diabetic dyslipoproteinemia. Experimental and Clinical Endocrinology & Diabetes 2003; 111: 239-245.

16.   Tambascia MA, Geloneze B, Repetto EM, Geloneze SR, Picolo M, Magro DO. Sibutramine enhances sensitivity ameliorating metabolic parameters in a double-blind, randomized, placebo-controlled trial. Diabetes Obesity & Metabolism 2003; 338-344.

17.   Salpeter S R, Greyber E, Pasternak GA, Salpeter EE. Risk of Fatal and Nonfatal Lactic Acidosis with Metformin Use in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis. Arch Intern Med 2003; 163: 2594-2602.

18.   McTigue KM, Harris R, Hemphill B, Lux L, Sutton S, Bunton A J, Lohr KN. Screening and Interventions for Obesity in Adults: Summary of the Evidence for the U.S. Preventive Services Task Force. Ann Intern Med 2003; 139: 933-949.

19.  Nisoli E, Carruba MO. A Benefit-risk Assessment of Sibutramine in the Management of Obesity. Drugs Safety 2003; 26: 1027-1048.

20.  Izkhakov E, Meltzer E, Rubinstein A. Pathogenesis and Management of Diabetic Dyslipidemia. Treat Endocrinol 2003; 2: 231-245.

21.   Fonseca V. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. Am J Med 2003; 115 (Suppl 8A): 42-48.

E2. Gokcel A, Gumurdulu Y, Karakose H, Ertorer EM, Tanaci N, Tutuncu NB, Guvener N. Evaluation of the Safety and Efficacy of Sibutramine, Orlistat, and Metformin in the Treatment of Obesity. Diabetes Obesity & Metabolism 2002; 4: 49-55.

1.     Bayes M, Rabasseda X, Prous JR. Gateways to Clinical Trials. Method Find Exp Clin 2002; 24: 525-551.

2.     Scheen AJ, Ernest PH. New antiobesity agents in type 2 diabetes: Overview of Clinical Trials with Sibutramine and Orlistat. Diabetes Metab 2002; 28: 437-445.

3.     Barbieri RL. Metformin for the Treatment of Polycystic Ovary Syndrome. Obstet Gynecol 2003; 101: 785-793.

4.     Misra A, Vikram NK. Insulin resistance syndrome (metabolic syndrome) and Asian Indians. Curr Sci India 2002; 83: 1483-1496.

5.     Ruis JS, Gonzalez DS, Fructuoso PA. Abuse potential of sibutramine. Med Clin-Barcelona 2003; 120: 639.

6.     Scheen AJ. Current management strategies for coexisting diabetes mellitus and obesity. Drugs 2003; 63: 1165-1184.

7.     Ryan DH. Use of sibutramine to treat obesity. Primary Care 2003; 30: 405-

8.     de Villar NGP, Loria Vi Monereo S. ‘Alternative’ drugs for obesity treatment : myth and reality. Med Clin-Barcelona 2003; 121: 500-510.

9.      Weaver JU, Syed AA.Insulin resistance and coronary artery disease: body mass index may have affected results. Diabetes Obes Metab 2004; 1: 78.

E3. Gokcel A, Baltali M, Tarim E, Bagis T, Gumurdulu Y, Karakose H, Yalcin F, Guvener N. Detection of Insulin Resistance in Turkish Adults: A Hospital Based Study. Diabetes Obesity & Metabolism 2003; 5: 126-130.

1.     Syed AA, Weaver JU. Insulin resistance and coronary artery disease: body mass index may

have affected results. Diabetes Obes Metab 2004; 6: 78.